Presence of Neuropathic Pain May Explain Poor Performances on Olfactory Testing in Diabetes Mellitus Patients
Identifieur interne : 001051 ( Main/Exploration ); précédent : 001050; suivant : 001052Presence of Neuropathic Pain May Explain Poor Performances on Olfactory Testing in Diabetes Mellitus Patients
Auteurs : Shauna Brady [Canada] ; Paul Lalli [Canada] ; Nisha Midha [Canada] ; Ayechen Chan [Canada] ; Alexandra Garven [Canada] ; Cynthia Chan [Canada] ; Cory Toth [Canada]Source :
- Chemical senses [ 0379-864X ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
Olfactory dysfunction in neurodegenerative conditions such as Parkinson's syndrome and Alzheimer's disease can hallmark disease onset. We hypothesized that patients with diabetes mellitus, a condition featuring peripheral and central neurodegeneration, would have decreased olfaction abilities. We examined participants with diabetic peripheral neuropathy, participants with diabetes without diabetic peripheral neuropathy, and control participants in blinded fashion using standardized Sniffin' Sticks. Diabetic peripheral neuropathy severity was quantified using the Utah Early Neuropathy Scale. Further subcategorization of diabetic peripheral neuropathy based on presence of neuropathic pain was performed with Douleur Neuropathique 4 Questionnaires. Participants with diabetes had decreased olfactory sensitivity, impaired olfactory discrimination abilities, and reduced odor identification skills when compared with controls. However, loss of olfaction ability was, at least partially, attributed to presence of neuropathic pain on subcategory assessment, although pain severity was not associated with dysfunction. Those participants with diabetes without diabetic peripheral neuropathy and those with diabetic peripheral neuropathy without neuropathic pain had similar olfactory function as controls in general. The presence of neuropathic pain, associated with limited attention and concentration, may explain at least a portion of the olfactory dysfunction witnessed in the diabetic patient population.
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aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Garven, Alexandra" sort="Garven, Alexandra" uniqKey="Garven A" first="Alexandra" last="Garven">Alexandra Garven</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary</s1><s2>Calgary, AB</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Chan, Cynthia" sort="Chan, Cynthia" uniqKey="Chan C" first="Cynthia" last="Chan">Cynthia Chan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary</s1><s2>Calgary, AB</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Toth, Cory" sort="Toth, Cory" uniqKey="Toth C" first="Cory" last="Toth">Cory Toth</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary</s1><s2>Calgary, AB</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author></analytic><series><title level="j" type="main">Chemical senses</title><title level="j" type="abbreviated">Chem. senses</title><idno type="ISSN">0379-864X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Chemical senses</title><title level="j" type="abbreviated">Chem. senses</title><idno type="ISSN">0379-864X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term><term>Neuralgia</term><term>Neuropathic pain</term><term>Neuropathy</term><term>Olfaction</term><term>Performance</term><term>Type 2 diabetes</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Névralgie</term><term>Douleur neuropathique</term><term>Performance</term><term>Olfaction</term><term>Diabète de type 2</term><term>Neuropathie</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory dysfunction in neurodegenerative conditions such as Parkinson's syndrome and Alzheimer's disease can hallmark disease onset. We hypothesized that patients with diabetes mellitus, a condition featuring peripheral and central neurodegeneration, would have decreased olfaction abilities. We examined participants with diabetic peripheral neuropathy, participants with diabetes without diabetic peripheral neuropathy, and control participants in blinded fashion using standardized Sniffin' Sticks. Diabetic peripheral neuropathy severity was quantified using the Utah Early Neuropathy Scale. Further subcategorization of diabetic peripheral neuropathy based on presence of neuropathic pain was performed with Douleur Neuropathique 4 Questionnaires. Participants with diabetes had decreased olfactory sensitivity, impaired olfactory discrimination abilities, and reduced odor identification skills when compared with controls. However, loss of olfaction ability was, at least partially, attributed to presence of neuropathic pain on subcategory assessment, although pain severity was not associated with dysfunction. Those participants with diabetes without diabetic peripheral neuropathy and those with diabetic peripheral neuropathy without neuropathic pain had similar olfactory function as controls in general. The presence of neuropathic pain, associated with limited attention and concentration, may explain at least a portion of the olfactory dysfunction witnessed in the diabetic patient population.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Brady, Shauna" sort="Brady, Shauna" uniqKey="Brady S" first="Shauna" last="Brady">Shauna Brady</name></region><name sortKey="Chan, Ayechen" sort="Chan, Ayechen" uniqKey="Chan A" first="Ayechen" last="Chan">Ayechen Chan</name><name sortKey="Chan, Cynthia" sort="Chan, Cynthia" uniqKey="Chan C" first="Cynthia" last="Chan">Cynthia Chan</name><name sortKey="Garven, Alexandra" sort="Garven, Alexandra" uniqKey="Garven A" first="Alexandra" last="Garven">Alexandra Garven</name><name sortKey="Lalli, Paul" sort="Lalli, Paul" uniqKey="Lalli P" first="Paul" last="Lalli">Paul Lalli</name><name sortKey="Midha, Nisha" sort="Midha, Nisha" uniqKey="Midha N" first="Nisha" last="Midha">Nisha Midha</name><name sortKey="Toth, Cory" sort="Toth, Cory" uniqKey="Toth C" first="Cory" last="Toth">Cory Toth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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